ZBP-89 reduces the cell death threshold in hepatocellular carcinoma cells by increasing caspase-6 and S phase cell cycle arrest
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AbstractZBP-89 inhibits the some tumor cells but its role in HCC is unknown. We investigated effect of ZBP-89 on cell death of 5 HCC cell lines with different status of p53. We found that ZBP-89 significantly induced cell death of all HCC cells particularly those with wild-type p53. The inhibition was well correlated with the induction of caspase-6 activity. The inhibition of caspase-6 abolished the effect of ZBP-89. ZBP-89 reduced the cells in G2-M but increased them in S phase. With the changes in caspase-6 and cell cycle, ZBP-89 greatly enhanced the killing effectiveness of 5-fluorouracil or staurosporine in HCC cells. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
All Author(s) ListChen GG, Chan UPF, Bai LC, Fung KY, Tessier A, To AKY, Merchant JL, Lai PBS
Journal nameCancer Letters
Volume Number283
Issue Number1
Pages52 - 58
LanguagesEnglish-United Kingdom
KeywordsCaspase-6; Cell cycle; Hepatocellular carcinoma; p53; Proliferation; ZBP-89
Web of Science Subject CategoriesOncology; ONCOLOGY

Last updated on 2020-31-03 at 02:34