Epidemiologic Risk Profile of Infection With Different Groups of Human Papillomaviruses
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AbstractThis study identified the age-specific prevalence and epidemiologic risk profile for infection with different groups and species of human papillomaviruses (HPV). Structured interview and HPV testing were conducted for 2,604 Chinese women self-referred for cervical screening. Independent risk factors for infection were identified by multiple logistic regressions. Overall, a major peak of HPV infection was observed at women aged 2630 years, and a minor peak at 46-55 years. This pattern was observed for high-risk, low-risk, and alpha-5/7/9 HPVs; but alpha-3/6 HPVs showed peaks of similar magnitudes in young and older women. Independent risk factors for HPV infection (all types combined) included younger age (OR [95% Cl] for >55 vs. <= 30 years = 0.22 [0.09-0.55]; 31-45 vs. <= 30 years = 0.57 [0.33-0.99]), having 4 lifetime sexual partners (2.28 [1.06-4.88]), and smoking (2.24 [1.22-4.10]). Young age and smoking were the most consistent independent risk factors observed across different HPV groups. The risk profile for high-risk HPV was similar to alpha-5/7/9. Single-type infection was associated with having more sexual partners, higher education level and oral contraception; whereas multiple-type infection was associated with smoking. In conclusion, a U-shaped age-specific prevalence curve was observed for HPV infection overall, but with a different pattern for different HPV species. Different HPV groups showed variations in their risk profiles. These data are useful for formulating preventative strategy for HPV-related diseases. Catch-up vaccination program in Hong Kong should cover a wider age group as the first peak of infection occurred relatively late. J. Med. Virol. 81:1635-1644, 2009. (C) 2009 Wiley-Liss, Inc.
All Author(s) ListChan PKS, Ho WCS, Wong MCS, Chang AR, Chor JSY, Yu MY
Name of ConferenceWONCA Asia Pacific Regional Conference
Start Date of Conference02/10/2008
End Date of Conference05/10/2008
Place of ConferenceMelbourne
Journal nameJournal of Medical Virology
Detailed descriptionTo ORKTS: Published online on 21 July 2009
Year2009
Month9
Day1
Volume Number81
Issue Number9
PublisherWiley: 12 months
Pages1635 - 1644
ISSN0146-6615
eISSN1096-9071
LanguagesEnglish-United Kingdom
Keywordscervical cancer; Chinese; epidemiology; human papillomavirus; risk factors
Web of Science Subject CategoriesVirology; VIROLOGY

Last updated on 2020-29-10 at 00:39