Radix Astragali and Radix Rehmanniae, the Principal Components of Two Antidiabetic Foot Ulcer Herbal Formulae, Elicit Viability-promoting Effects on Primary Fibroblasts Cultured from Diabetic Foot Ulcer Tissues
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AbstractOver 194 million people suffer from diabetes worldwide. The improper control of diabetes may result in diabetic foot ulcer or even amputation. Herbal medicine provides a means for treating diabetic foot ulcers for a large population in developing countries. The wound healing-enhancing activities of the principal herbs, Radix Astragali (RA) and Radix Rehmanniae (RR) in two clinically efficacious Chinese herbal formulae were studied in primary fibroblasts from diabetic foot ulcer patients. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed that RA and RR significantly enhanced the viability of fibroblasts isolated from foot ulcers of diabetic patients, even from those with no response to insulin treatment. The results in this study indicate that fibroblast viability enhancement effects of RA and RR likely underlie the healing effects of F1 and F2 in diabetic foot ulcers. Copyright (c) 2009 John Wiley & Sons, Ltd.
All Author(s) ListLau TW, Chan YW, Lau CP, Lau KM, Lau CBS, Fung KP, Leung PC, Ho YY
Journal namePhytotherapy Research
Year2009
Month6
Day1
Volume Number23
Issue Number6
PublisherWiley: 12 months
Pages809 - 815
ISSN0951-418X
eISSN1099-1573
LanguagesEnglish-United Kingdom
KeywordsChinese medicine; diabetic mellitus; fibroblast; foot ulcer; granulation tissue; wound healing
Web of Science Subject CategoriesChemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-31-03 at 02:21