Development and validation of the functional assessment of cancer therapy nasopharyngeal cancer subscale
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We aimed to develop a quality-of-life subscale for nasopharyngeal carcinoma (NPC) and validate the functional assessment of cancer therapy-nasopharyngeal (FACT-NP).


The FACT-NP was tested cross-sectionally in survivors of postirradiated NPC (n = 357) and was administered to newly diagnosed patients (n = 160) before, at the end of, and 3 months after radiotherapy (RT).


Each FACT-NP domain was internally consistent (Cronbach's alpha = 0.87–0.90). The test–retest reliability for each subscale was satisfactory (intraclass correlation coefficient = .73–.88). Concurrent validity was suggested by the moderate to strong correlations between the FACT-NP and the Quality of Life-Radiation Therapy Instrument-Head and Neck (QOL-RTI-H&N) subscales (Pearson r = .39–.84). The FACT-NP was responsive to clinical changes from pretreatment to 3 months after RT (effect sizes > 0.6 for clinically relevant subscales). The pooled data for multitrait scaling analysis showed satisfactory item internal consistency and item discriminant validity (100% and 90% scaling success, respectively).


The FACT-NP is a reliable and valid instrument for measuring QOL in patients with NPC.
All Author(s) ListTong MCF, Lo PSY, Wong KH, Yeung RMW, van Hasselt CA, Eremenco S, Cella D
Journal nameHead and Neck
Volume Number31
Issue Number6
Pages738 - 747
LanguagesEnglish-United Kingdom
Keywordsclinical outcome, functional assessment, nasopharyngeal carcinoma, quality of life, radiation therapy
Web of Science Subject CategoriesOtorhinolaryngology; OTORHINOLARYNGOLOGY; Surgery; SURGERY

Last updated on 2020-16-10 at 00:46