A study of bone marrow and subcutaneous fatty acid composition in subjects of varying bone mineral density
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摘要Osteoporosis is associated with an increase in marrow fat. Fats, particularly polyunsaturated fats, either ill co-cultures or diet, have been shown to significantly influence bone remodeling. Whether the increase in marrow fat seen in osteoporosis is also associated with a change in fatty acid composition is not known. This Study was undertaken to investigate the fatty acid composition in subjects of varying bone mineral density (BMD). Samples of marrow fat and subcutaneous fat from 126 subjects (98 females, 34 males, mean age 69.7 +/- 10.5 years) undergoing Orthopedic surgery were analyzed for fatty acid composition by gas chromatography. These results were correlated with BMD assessed by DXA. A total of 22 fatty acids were identified in marrow and subcutaneous fat. Significant differences in fatty acid composition existed between marrow and subcutaneous fat as well as between marrow fat samples obtained from the proximal femur and proximal tibia. Other than cis-7-hexadecenoic acid [C16:1 (n=9)] and docosanoic acid [C22:0], no difference in marrow fatty acid composition was evident between subject groups of varying BMD (normal, low bone mass, and osteoporosis). In conclusion, there exists a wide range of individual fatty acids in marrow fat. Marrow fatty acid composition differs from that Of Subcutaneous fat and varies between predominantly erythropoetic and fatty marrow sites. Other than cis-7-hexadecenoic acid [C16:1 (n=9)] and docosanoic acid [C22:0], no difference in marrow fatty acid composition was evident between subjects of varying BMD. (C) 2009 Elsevier Inc. All Fights reserved.
著者Griffith JF, Yeung DKW, Ahuja AT, Choy CWY, Mei WY, Lam SSL, Lam TP, Chen ZY, Leung PC
期刊名稱BONE
出版年份2009
月份6
日期1
卷號44
期次6
出版社Elsevier
頁次1092 - 1096
國際標準期刊號8756-3282
電子國際標準期刊號1873-2763
語言英式英語
關鍵詞Bone mineral density, Fatty acids, Marrow fat, Polyunsaturated fatty acids, Subcutaneous fat
Web of Science 學科類別Endocrinology & Metabolism; ENDOCRINOLOGY & METABOLISM

上次更新時間 2021-26-01 於 01:01