Antihyperglycemic and Antioxidative Effects of a Herbal Formulation of Radix Astragali, Radix Codonopsis and Cortex Lycii in a Mouse Model of Type 2 Diabetes Mellitus
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AbstractThere is emerging evidence that the generation of reactive oxygen species (ROS), which leads to dysfunction of pancreatic beta-cells, is a major factor in the development of type 2 diabetes mellitus. Antioxidation is one of the therapeutic strategies to overwhelm the imbalance in ROS production. In this study, a herbal formulation SR10, comprising Radix Astragali, Radix Codonopsis and Cortex Lycii, was examined for its antidiabetic and antioxidative effects using the diabetic +db/+db mouse model. The results showed that SR10 was effective in decreasing the blood glucose level in chronic treatment by improving beta-cell function. The activities and expression of antioxidant enzymes, catalase and superoxide dismutase, were up-regulated when treated with SR10. Moreover, SR10 treatment did not exhibit any toxic effect to the host. Copyright (C) 2008 John Wiley & Sons, Ltd.
All Author(s) ListChan JYW, Lam FC, Leung PC, Che CT, Fung KP
Journal namePhytotherapy Research
Volume Number23
Issue Number5
PublisherWiley: 12 months
Pages658 - 665
LanguagesEnglish-United Kingdom
Keywords+db/ plus db mouse; antioxidant enzymes; SR10
Web of Science Subject CategoriesChemistry, Medicinal; CHEMISTRY, MEDICINAL; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2021-13-01 at 00:25