MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells
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AbstractMicroRNAs (miRNAs) are non-protein-cocling RNAs that function as post-transcriptional gene regulators. Recent evidence has shown that miRNA plays a pivotal role in the development of many cancers including glioma, a lethal brain cancer. We have recently compared the miRNA expression profiles between normal brain and glioma tissues from Chinese patients by miRNA microarray and identified a panel of differentially expressed miRNAs. Here, we studied the function of one miRNA, miR-15b, in glioma carcinogenesis and elucidated its down stream targets. Over-expression of miR-15b resulted in cell cycle arrest at G0/G1 phase while suppression of miR-15b expression resulted in a decrease of cell populations in G0/G1 and a corresponding increase of cell populations in S phase. We further showed that CCNE1 (encoding cyclin E1) is one of the downstream targets of miR-15b. Taken together, our findings indicate that miR-15b regulates cell cycle progression ill glioma cells by targeting cell cycle-related molecules. (c) 2009 Elsevier Inc. All rights reserved.
All Author(s) ListXia HP, Qi YT, Ng SS, Chen XN, Chen S, Fang MR, Li D, Zhao Y, Ge RG, Li G, Chen YC, He ML, Kung HF, Lai LH, Lin MC
Journal nameBiochemical and Biophysical Research Communications
Volume Number380
Issue Number2
Pages205 - 210
LanguagesEnglish-United Kingdom
KeywordsCCNE1; Cell cycle; Glioblastoma; MicroRNA; MiR-15b
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS

Last updated on 2020-28-11 at 23:55