Selenium nanoparticles fabricated in Undaria pinnatifida polysaccharide solutions induce mitochondria-mediated apoptosis in A375 human melanoma cells
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AbstractSelenium nanoparticle (Nano-Se) is a novel Se species with novel biological activities and low toxicity. In the present study, we demonstrated a simple method for synthesis of size-controlled Nano-Se by adding Undaria pinnatifida polysaccharides to the redox system of selenite and ascorbic acid. A panel of four human cancer cell lines was shown to be susceptible to Nano-Se, with IC50 values ranging from 3.0 to 14.1 mu M. Treatment of A375 human melanoma cells with the Nano-Se resulted in dose-dependent cell apoptosis as indicated by DNA fragmentation and phosphatidylserine translocation. Further investigation on intracellular mechanisms found that Nano-Se treatment triggered apoptotic cell death in A375 cells with the involvement of oxidative stress and mitochondrial dysfunction. Our results suggest that Nano-Se may be a candidate for further evaluation as a chemopreventive and chemotherapeutic agent for human cancers, especially melanoma cancer. (C) 2008 Elsevier B.V. All rights reserved.
All Author(s) ListChen T, Wong YS, Zheng W, Bai Y, Huang L
Journal nameColloids and Surfaces B: Biointerfaces
Volume Number67
Issue Number1
Pages26 - 31
LanguagesEnglish-United Kingdom
KeywordsApoptosis; Mitochondria; Nanoparticle; Selenium; Undaria pinnatifida polysaccharide
Web of Science Subject CategoriesBiophysics; BIOPHYSICS; Chemistry; Chemistry, Physical; CHEMISTRY, PHYSICAL; Materials Science; Materials Science, Biomaterials; MATERIALS SCIENCE, BIOMATERIALS

Last updated on 2020-29-10 at 00:34