A mannose/glucose-specific lectin from Chinese evergreen chinkapin (Castanopsis chinensis)
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AbstractA mannose/glucose-specific lectin has been purified from Chinese evergreen chinkapin (Costanopsis chinensis) seeds, one of the most popular foods in East Asia. This lectin, designated as CCL, exhibited hemagglutinating activity in mouse and rabbit erythrocytes. It displayed a single band with a molecular mass of 29 kDa in SDS-PAGE and a 120-kDa peak in gel-filtration on Superdex-200. Its hemagglutinating activity was stable in the pH range 6-12 and at temperatures below 60 degrees C. The N-terminal amino acid sequence of CCL differed from those of other lectins in the same family. CCL inhibited the Proliferation of HepG2 cells and adult emergence in fruitflies. CCL exhibited mitogenic activity toward Mouse splenocytes, and induced nitric oxide production from mouse peritoneal macrophages but was devoid of inhibitory activity toward mycelial growth and HIV-1 reverse transcriptase. (c) 2008 Elsevier B.V. All rights reserved.
All Author(s) ListWong JH, Chan HYE, Ng TB
Journal nameBBA - General Subjects
Detailed descriptionTo ORKTS: doi: 10.1016/j.bbagen.2008.05.007
Year2008
Month9
Day1
Volume Number1780
Issue Number9
PublisherElsevier
Pages1017 - 1022
ISSN0304-4165
eISSN1872-8006
LanguagesEnglish-United Kingdom
KeywordsCastanopsis chinensis; isolation; lectin
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Biophysics; BIOPHYSICS

Last updated on 2020-03-07 at 02:25