Engineering of pharmaceutical materials: An industrial perspective
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AbstractCrystal engineering provides a rational approach to solving formulation, processing and product performance problems. This review discusses how the concept of crystal engineering can be judiciously utilized to manipulate the solid-state properties of drugs and excipients for successful pharmaceutical formulation and process development. Existing and emerging manufacturing as well as co-processing technologies being applied in the pharmaceutical industry are also presented together with selected examples of crystal form design, crystal form selection and crystal modifications for illustration purposes. (C) 2007 Wiley-Liss, Inc. and the American Pharmacists Association.
All Author(s) ListChow K, Tong HHY, Lum S, Chow AHL
Journal nameJournal of Pharmaceutical Sciences
Volume Number97
Issue Number8
Pages2855 - 2877
LanguagesEnglish-United Kingdom
Keywordscrystal engineering; crystallization; formulation; particle size; pharmaceutical manufacturing; polymorphism; preformulation; selection of salt forms
Web of Science Subject CategoriesChemistry; Chemistry, Medicinal; CHEMISTRY, MEDICINAL; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY; Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-14-10 at 02:02