Inhibition of HBV gene expression and replication by stably expressed interferon-alpha 1 via adeno-associated viral vectors
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AbstractBackground interferon-alpha 2 (IFN alpha 2) is routinely used for anti-hepatitis B virus (HBV) treatment. However, the therapeutic efficiency is unsatisfactory, particularly in East Asia. Such inefficiency might be a result of the short half-life, relatively low local concentration and strong side-effects of interferons. Frequent and repeated injection is also a big burden for patients. in the present study, a single dose of vector-delivered IFN alpha 1 was tested for its anti-HBV effects.
All Author(s) ListLi Z, Yao H, Ma Y, Dong QM, Chen YC, Peng Y, Zheng BJ, Huang JD, Chan CY, Lin MC, Sung JJ, Yuen KY, Kung HF, He ML
Journal nameJournal of Gene Medicine
Volume Number10
Issue Number6
PublisherWiley: 12 months
Pages619 - 627
LanguagesEnglish-United Kingdom
Keywordsadeno-associated virus; gene therapy; hepatitis B virus; hydrodynamic transfection; interferon-alpha 1
Web of Science Subject CategoriesBiotechnology & Applied Microbiology; BIOTECHNOLOGY & APPLIED MICROBIOLOGY; Genetics & Heredity; GENETICS & HEREDITY; Medicine, Research & Experimental; MEDICINE, RESEARCH & EXPERIMENTAL; Research & Experimental Medicine

Last updated on 2020-23-11 at 00:29