Physical characterization of oleanolic acid nonsolvate and solvates prepared by solvent recrystallization
Publication in refereed journal

香港中文大學研究人員

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摘要Oleanolic acid is a naturally occurring compound used clinically in China for the treatment of hepatitis B. The solid-state chemistry of oleanolic acid recrystallized from a variety of solvents was investigated. Glassy materials were prepared from dichloromethane and chloroform solvents. The oleanolic acid non-solvate prepared from acetone (OA-acetone), and the two oleanolic acid solvates prepared from methanol (OA-methanol) and ethanol (OA-ethanol) were physicochemically characterized. Upon desolvation, both the methanol and ethanol solvates were found to undergo phase transformation to a crystalline phase similar to OA-acetone around 190-195 degrees C. The PXRD patterns of commercial pharmaceutical grade OA and the OA-methanol were similar, so the commercial form is probably desolvated oleanolic acid methanol solvate. (c) 2007 Elsevier B.V. All rights reserved.
著者Tong HHY, Wu HB, Zheng Y, Xi J, Chow AHL, Chan CK
期刊名稱International Journal of Pharmaceutics
出版年份2008
月份5
日期1
卷號355
期次1-2
出版社Elsevier
頁次195 - 202
國際標準期刊號0378-5173
電子國際標準期刊號1873-3476
語言英式英語
關鍵詞oleanolic acid; solid-state transition; solvates; solvent recrystallization
Web of Science 學科類別Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

上次更新時間 2020-14-09 於 01:31