Physical characterization of oleanolic acid nonsolvate and solvates prepared by solvent recrystallization
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AbstractOleanolic acid is a naturally occurring compound used clinically in China for the treatment of hepatitis B. The solid-state chemistry of oleanolic acid recrystallized from a variety of solvents was investigated. Glassy materials were prepared from dichloromethane and chloroform solvents. The oleanolic acid non-solvate prepared from acetone (OA-acetone), and the two oleanolic acid solvates prepared from methanol (OA-methanol) and ethanol (OA-ethanol) were physicochemically characterized. Upon desolvation, both the methanol and ethanol solvates were found to undergo phase transformation to a crystalline phase similar to OA-acetone around 190-195 degrees C. The PXRD patterns of commercial pharmaceutical grade OA and the OA-methanol were similar, so the commercial form is probably desolvated oleanolic acid methanol solvate. (c) 2007 Elsevier B.V. All rights reserved.
All Author(s) ListTong HHY, Wu HB, Zheng Y, Xi J, Chow AHL, Chan CK
Journal nameInternational Journal of Pharmaceutics
Volume Number355
Issue Number1-2
Pages195 - 202
LanguagesEnglish-United Kingdom
Keywordsoleanolic acid; solid-state transition; solvates; solvent recrystallization
Web of Science Subject CategoriesPharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-14-10 at 01:51