Isolated tumor cells and circulating CK20 mRNA in pN0 colorectal cancer patients
Publication in refereed journal


摘要Micrometastases in lymph nodes and blood may provide important prognostic information. In this study, cytokeratin 20 (CK20) positive cells in lymph nodes and circulating CK20 mRNA were studied using 57 paraffin-embedded lymph node specimens and blood from 24 patients with pN0 colorectal cancer (CRC), respectively. Results showed that 29 out of 56 (52%) lymph node specimens had CK20-positive cells (range: 1-35). Follow-up of the patients for 12 months indicated that 4 patients (7%) had CRC metastases to liver, lung, and bone. In addition, 8 out of 24 (33%) samples had at least 2-fold circulating CK20 mRNA expression higher than the pooled normal sample. This study provides evidence that CK20-positive cells were found in the lymph nodes and differentially expressed circulating CK20 mRNA was also detected in the blood from patients with pN0 CRC. Long-term follow-up is necessary to study their prognostic use in patients with nonmetastatic CRC.
著者Wong CSC, Cheung MT, Ma BBY, Hui EP, Chan ACL, Chan CK, Lee KC, Cheuk W, Lam MYY, Wong MCK, Chan CML, Chan JKC, Chan ATC
期刊名稱International Journal of Surgical Pathology
出版社SAGE Publications (UK and US)
頁次119 - 126
關鍵詞CK20; CK20 mRNA; colorectal cancer patients; lymph nodes; pN0
Web of Science 學科類別Pathology; PATHOLOGY; Surgery; SURGERY

上次更新時間 2020-26-11 於 00:45