A Bowman-Birk trypsin inhibitor with antiproliferative activity from Hokkaido large black soybeans
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AbstractA trypsin inhibitor, with an N-terminal sequence highly homologous to those of 8-kDa Bowman-Birk trypsin inhibitors, was isolated from the seeds of Hokkaido large black soybeans. The trypsin inhibitor was unadsorbed on SP-Sepharose but adsorbed on DEAF-cellulose and Mono Q. It inhibited proliferation in breast cancer (MCF-7) cells and hepatoma (Hep G2) cells with an IC50 of 35 and 140 mu M, respectively. The trypsin inhibitory activity of the inhibitor was completely preserved after exposure to temperatures up to 100 degrees C for 30 min and to the pH range 2-13 for the same duration. The trypsin inhibitor inhibited HIV-1 reverse transcriptase with an IC50 of 38 gm. but was devoid of antifungal activity toward Fusarium oxysporum and Mycosphaerella arachidicola. Copyright (C) 2007 European Peptide Society and John Wiley & Sons, Ltd.
All Author(s) ListHo VSM, Ng TB
Journal nameJournal of Peptide Science
Volume Number14
Issue Number3
PublisherWiley: 12 months
Pages278 - 282
LanguagesEnglish-United Kingdom
Keywordsantiproliferative; black soybean; trypsin inhibitor
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Chemistry; Chemistry, Analytical; CHEMISTRY, ANALYTICAL

Last updated on 2021-14-05 at 01:32