Volumetric magnetic resonance imaging correlates of the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment neuropsychology protocols
Publication in refereed journal


摘要Background: Vascular cognitive impairment (VCI) refers to the entire spectrum of cognitive dysfunction attributable to vascular changes in the brain. The objective of this study is to evaluate magnetic resonance imaging (MRI) correlates of performance on the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network (NINDS-CSN) VCI neuropsychology protocols. Method: Fifty ischemic stroke patients and 50 normal elderly persons completed the VCI protocols and MRI. Relationships between the four cognitive domains (executive/activation, language, visuospatial, and memory) and three protocol (60-, 30-, and 5-min) summary scores with MRI measures of volumes of white matter hyperintensities (WMH) and global brain and hippocampal atrophy were assessed using linear regression. Results: All cognitive domain scores were associated with WMH volume and, with the exception of language domain, with global atrophy. Additional relationships were found between executive/activation and language domains with left hippocampal volume, visuospatial domain with right hippocampal volume, and memory domain with bilateral hippocampal volumes. All protocol summary scores showed comparable relationships with WMH and hippocampal volumes, with additional relationships found between the 60- and 30-min protocols with global brain volume. Conclusions: Performance on the NINDS-CSN VCI protocols reflects underlying volumetric brain changes implicated in cognitive dysfunctions in VCI.
著者Wong A, Wang DF, Black SE, Nyenhuis DL, Shi L, Chu WCW, Xiong YY, Au L, Lau A, Chan AYY, Wong LKS, Mok V
期刊名稱Journal of Clinical and Experimental Neuropsychology
出版社Taylor & Francis (Routledge): STM, Behavioural Science and Public Health Titles
頁次1004 - 1012
關鍵詞Cognitive assessment; Magnetic resonance imaging; Neuropsychology; Stroke; Vascular cognitive impairment
Web of Science 學科類別Clinical Neurology; Neurosciences & Neurology; Psychology; Psychology, Clinical

上次更新時間 2021-24-09 於 00:21