Volumetric magnetic resonance imaging correlates of the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment neuropsychology protocols
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AbstractBackground: Vascular cognitive impairment (VCI) refers to the entire spectrum of cognitive dysfunction attributable to vascular changes in the brain. The objective of this study is to evaluate magnetic resonance imaging (MRI) correlates of performance on the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network (NINDS-CSN) VCI neuropsychology protocols. Method: Fifty ischemic stroke patients and 50 normal elderly persons completed the VCI protocols and MRI. Relationships between the four cognitive domains (executive/activation, language, visuospatial, and memory) and three protocol (60-, 30-, and 5-min) summary scores with MRI measures of volumes of white matter hyperintensities (WMH) and global brain and hippocampal atrophy were assessed using linear regression. Results: All cognitive domain scores were associated with WMH volume and, with the exception of language domain, with global atrophy. Additional relationships were found between executive/activation and language domains with left hippocampal volume, visuospatial domain with right hippocampal volume, and memory domain with bilateral hippocampal volumes. All protocol summary scores showed comparable relationships with WMH and hippocampal volumes, with additional relationships found between the 60- and 30-min protocols with global brain volume. Conclusions: Performance on the NINDS-CSN VCI protocols reflects underlying volumetric brain changes implicated in cognitive dysfunctions in VCI.
All Author(s) ListWong A, Wang DF, Black SE, Nyenhuis DL, Shi L, Chu WCW, Xiong YY, Au L, Lau A, Chan AYY, Wong LKS, Mok V
Journal nameJournal of Clinical and Experimental Neuropsychology
Volume Number37
Issue Number9
PublisherTaylor & Francis (Routledge): STM, Behavioural Science and Public Health Titles
Pages1004 - 1012
LanguagesEnglish-United Kingdom
KeywordsCognitive assessment; Magnetic resonance imaging; Neuropsychology; Stroke; Vascular cognitive impairment
Web of Science Subject CategoriesClinical Neurology; Neurosciences & Neurology; Psychology; Psychology, Clinical

Last updated on 2021-15-09 at 01:09