Sensitivity and Robustness Enhancements by Using a V-Shape Ion Funnel in FTICR-MS
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AbstractIn this paper, a new configuration of the ion funnel interface (i.e., V-shape ion funnel (V-IF)) for high ion transmission efficiency and robustness enhancement was developed and implemented on FTICR-MS. The performance of the V-IF was compared with that of a home-built orthogonal ion funnel. An order of magnitude of improvement in sensitivity was achieved for various peptides and proteins. The performance of the instrument was maintained for a long period by neutral molecule removal. Other ion transmission patterns, such as gentle ion transmission, adduct ion removal, and radio frequency (RF)-driven collision induced dissociation (OD), was also realized in V-IF by varying the RF potentials. V-IF is believed to be a novel ion guide that has promising applications in mass spectrometry.
All Author(s) ListDeng LL, Chen XF, Li W, Wang Z, Wong YE, Chat TWD
Journal nameAnalytical Chemistry
Year2015
Month8
Day18
Volume Number87
Issue Number16
PublisherAmerican Chemical Society
Pages8073 - 8077
ISSN0003-2700
eISSN1520-6882
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesChemistry; Chemistry, Analytical

Last updated on 2020-24-11 at 00:43