Rapid endosomal escape of prickly nanodiamonds: implications for gene delivery
Publication in refereed journal


引用次數
替代計量分析
.

其它資訊
摘要The prickly nanodiamonds easily entered cells via endocytosis followed by unique intracellular translocation characteristics-quick endosomal escape followed by stable residence in cytoplasm. Endosomal membrane rupturing is identified as the major route of nanodiamonds' escaping the vesicle confinement and to the cytoplasm. Little cytotoxicity is observed to associate with the nanodiamonds' cytosolic release. Such features enable its application for gene delivery, which requires both effective cellular uptake and cytosolic release of the gene. Taking green fluorescent protein gene as an example, we demonstrate the successful cytosolic delivery and expression of such a gene using the prickly nanodiamonds as carrier.
著者Chu ZQ, Miu KK, Lung PS, Zhang SL, Zhao SS, Chang HC, Lin G, Li Q
期刊名稱Scientific Reports
詳細描述To ORKTS: doi: 10.1038/srep11661
出版年份2015
月份6
日期30
卷號5
出版社NATURE PUBLISHING GROUP
國際標準期刊號2045-2322
電子國際標準期刊號2045-2322
語言英式英語
Web of Science 學科類別Multidisciplinary Sciences; Science & Technology - Other Topics

上次更新時間 2020-10-10 於 23:30