Rapid endosomal escape of prickly nanodiamonds: implications for gene delivery
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AbstractThe prickly nanodiamonds easily entered cells via endocytosis followed by unique intracellular translocation characteristics-quick endosomal escape followed by stable residence in cytoplasm. Endosomal membrane rupturing is identified as the major route of nanodiamonds' escaping the vesicle confinement and to the cytoplasm. Little cytotoxicity is observed to associate with the nanodiamonds' cytosolic release. Such features enable its application for gene delivery, which requires both effective cellular uptake and cytosolic release of the gene. Taking green fluorescent protein gene as an example, we demonstrate the successful cytosolic delivery and expression of such a gene using the prickly nanodiamonds as carrier.
All Author(s) ListChu ZQ, Miu KK, Lung PS, Zhang SL, Zhao SS, Chang HC, Lin G, Li Q
Journal nameScientific Reports
Detailed descriptionTo ORKTS: doi: 10.1038/srep11661
Year2015
Month6
Day30
Volume Number5
PublisherNATURE PUBLISHING GROUP
ISSN2045-2322
eISSN2045-2322
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesMultidisciplinary Sciences; Science & Technology - Other Topics

Last updated on 2020-01-10 at 00:04