A "Developmental Hourglass" in Fungi
Publication in refereed journal


摘要The "developmental hourglass" concept suggests that intermediate developmental stages are most resistant to evolutionary changes and that differences between species arise through divergence later in development. This high conservation during middevelopment is illustrated by the "waist" of the hourglass and it represents a low probability of evolutionary change. Earlier molecular surveys both on animals and on plants have shown that the genes expressed at the waist stage are more ancient and more conserved in their expression. The existence of such a developmental hourglass has not been explored in fungi, another eukaryotic kingdom. In this study, we generated a series of transcriptomic data covering the entire lifecycle of a model mushroom-forming fungus, Coprinopsis cinerea, and we observed a molecular hourglass over its development. The "young fruiting body" is the stage that expresses the evolutionarily oldest (lowest transcriptome age index) transcriptome and gives the strongest signal of purifying selection (lowest transcriptome divergence index). We also demonstrated that all three kingdoms-animals, plants, and fungi-display high expression levels of genes in "information storage and processing" at the waist stages, whereas the genes in "metabolism" become more highly expressed later. Besides, the three kingdoms all show underrepresented "signal transduction mechanisms" at the waist stages. The synchronic existence of a molecular "hourglass" across the three kingdoms reveals a mutual strategy for eukaryotes to incorporate evolutionary innovations.
著者Cheng XJ, Hui JHL, Lee YY, Law PTW, Kwan HS
期刊名稱Molecular Biology and Evolution
出版社Oxford University Press (OUP): Molecular Biology and Evolution
頁次1556 - 1566
關鍵詞"developmental hourglass"; Coprinopsis; mushroom-forming fungus; transcriptomics
Web of Science 學科類別Biochemistry & Molecular Biology; Evolutionary Biology; Genetics & Heredity

上次更新時間 2022-13-01 於 00:00