Novel anti-angiogenic effects of aromatic-turmerone, essential oil isolated from spice turmeric
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AbstractAngiogenesis is essential for tumor growth and there is a continuing need for exploring new anti-angiogenic agents from natural products including herbs. Aromatic (Ar)-turmerone isolated from the rhizome of Curcuma longa Linn. (Turmeric) exhibits anti-tumor and immunomodulatory activities. In this study, the anti-angiogenic effects of Ar-turmerone were evaluated in human microvascular endothelial cells, zebrafish and Matrigel plugs mouse models. The data obtained indicate that Ar-turmerone treatment significantly inhibits the proliferation, tube formation and motility of HMEC-1 cells at non-cytotoxic concentrations (4.6-9.2 mu M, p <0.05). The mRNA expressions of metalloproteinase-2 and -9 as well as adhesion molecules could be down-regulated by Ar-turmerone at 18.4 mu M (p <0.05). In zebrafish model, the new blood vessel growth in embryos was significantly blocked by Ar-turmerone treatment (12.5-25 mu g/mL medium). The bFGF-induced blood vessel formation in Matrigel plugs in C57BL/6 mice was suppressed by Ar-turmerone (25-50 mu g/mL Matrigel). Thus, the in vitro and in vivo anti-angiogenic activities of Ar-turmerone were demonstrated for the first time. The findings suggest that such a component of turmeric essential oil has the potential to be further developed as an anti-angiogenic agent. (C) 2015 Elsevier Ltd. All rights reserved.
All Author(s) ListYue GGL, Kwok HF, Lee JKM, Jiang L, Chan KM, Cheng L, Wong ECW, Leung PC, Fung KP, Lau CBS
Journal nameJournal of Functional Foods
Volume Number15
Pages243 - 253
LanguagesEnglish-United Kingdom
KeywordsAngiogenesis; Aromatic-turmerone; Curcuma longa; Endothelial cells; VEGF; Zebrafish
Web of Science Subject CategoriesFood Science & Technology

Last updated on 2020-29-05 at 01:35