Effect of Extended-Release Niacin/Laropiprant Combination on Plasma Adiponectin and Insulin Resistance in Chinese Patients with Dyslipidaemia
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摘要Objectives. This study examined whether the increase of adiponectin associated with extended-release (ER) niacin/laropiprant combination attenuates the adverse effect of niacin on glucose and insulin resistance in Hong Kong Chinese patients with dyslipidaemia. Methods. Patients (N = 121) were treated with ER niacin/laropiprant 1 g/20 mg for 4 weeks and then the dose was doubled for an additional 8 weeks. Measurements of fasting lipids, glucose, insulin, and adiponectin were performed at baseline and during the study. Results. There were significant (P < 0.001) increases in glucose (9.4 +/- 13.1%), insulin (70.2 +/- 91.0%), HOMA-IR (87.8 +/- 103.9%), and adiponectin (169.3 +/- 111.6%). The increase in adiponectin was significantly associated with increase in glucose (r = 0.221, P < 0.05), insulin (r = 0.184, P < 0.05), and HOMA-IR (r = 0.237, P < 0.01) and the association remained significant after adjustment for changes in body weight or body fat mass. Conclusion. Treatment with ER niacin/laropiprant led to a significant increase in adiponectin levels but worsening of glucose levels and insulin resistance, and the increase in adiponectin and insulin resistance were correlated suggesting the increase in adiponectin did not ameliorate the deterioration in insulin resistance.
著者Hu M, Yang YL, Masuda D, Yamashita S, Tomlinson B
期刊名稱Disease Markers
出版年份2015
月份1
日期1
出版社Hindawi Publishing Corporation
國際標準期刊號0278-0240
電子國際標準期刊號1875-8630
語言英式英語
Web of Science 學科類別Biotechnology & Applied Microbiology; Genetics & Heredity; Medicine, Research & Experimental; Pathology; Research & Experimental Medicine

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