A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients
Publication in refereed journal


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摘要Background & Aims: Aberrant chromatin modification is a key feature of hepatocellular carcinoma (HCC), which is characterized by strong sexual dimorphism. Both enhancer of zeste homolog 2 (EZH2) and cell cycle-related kinase (CCRK) contribute to hepatocarcinogenesis, yet whether the two oncogenic factors have functional crosstalk is unknown.
著者Feng H, Yu Z, Tian Y, Lee YY, Li MS, Go MYY, Cheung YS, Lai PBS, Chan AML, To KF, Chan HLY, Sung JJY, Cheng ASL
期刊名稱Journal of Hepatology
出版年份2015
月份5
日期1
卷號62
期次5
出版社Elsevier
頁次1100 - 1111
國際標準期刊號0168-8278
電子國際標準期刊號1600-0641
語言英式英語
關鍵詞Androgen receptor; Chromatin modifications; Gender disparity; Hepatocellular carcinoma; Kinase
Web of Science 學科類別Gastroenterology & Hepatology

上次更新時間 2020-31-07 於 23:08