A CCRK-EZH2 epigenetic circuitry drives hepatocarcinogenesis and associates with tumor recurrence and poor survival of patients
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AbstractBackground & Aims: Aberrant chromatin modification is a key feature of hepatocellular carcinoma (HCC), which is characterized by strong sexual dimorphism. Both enhancer of zeste homolog 2 (EZH2) and cell cycle-related kinase (CCRK) contribute to hepatocarcinogenesis, yet whether the two oncogenic factors have functional crosstalk is unknown.
All Author(s) ListFeng H, Yu Z, Tian Y, Lee YY, Li MS, Go MYY, Cheung YS, Lai PBS, Chan AML, To KF, Chan HLY, Sung JJY, Cheng ASL
Journal nameJournal of Hepatology
Volume Number62
Issue Number5
Pages1100 - 1111
LanguagesEnglish-United Kingdom
KeywordsAndrogen receptor; Chromatin modifications; Gender disparity; Hepatocellular carcinoma; Kinase
Web of Science Subject CategoriesGastroenterology & Hepatology

Last updated on 2021-11-04 at 23:48