Copy number gain of granulin-epithelin precursor (GEP) at chromosome 17q21 associates with overexpression in human liver cancer
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摘要Background: Granulin-epithelin precursor (GEP), a secretory growth factor, demonstrated overexpression in various human cancers, however, mechanism remain elusive. Primary liver cancer, hepatocellular carcinoma (HCC), ranks the second in cancer-related death globally. GEP controlled growth, invasion, metastasis and chemo-resistance in liver cancer. Noted that GEP gene locates at 17q21 and the region has been frequently reported to be amplified in subset of HCC. The study aims to investigate if copy number gain would associate with GEP overexpression.
著者Yung MK, Lo KW, Yip CW, Chung GTY, Tong CYK, Cheung PFY, Cheung TT, Poon RTP, So S, Fan ST, Cheung ST
期刊名稱BMC Cancer
出版年份2015
月份4
日期11
卷號15
出版社BIOMED CENTRAL LTD
國際標準期刊號1471-2407
語言英式英語
關鍵詞Chromosome gain; Granulin-epithelin precursor; Liver cancer
Web of Science 學科類別Oncology

上次更新時間 2020-22-10 於 00:29