Copy number gain of granulin-epithelin precursor (GEP) at chromosome 17q21 associates with overexpression in human liver cancer
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AbstractBackground: Granulin-epithelin precursor (GEP), a secretory growth factor, demonstrated overexpression in various human cancers, however, mechanism remain elusive. Primary liver cancer, hepatocellular carcinoma (HCC), ranks the second in cancer-related death globally. GEP controlled growth, invasion, metastasis and chemo-resistance in liver cancer. Noted that GEP gene locates at 17q21 and the region has been frequently reported to be amplified in subset of HCC. The study aims to investigate if copy number gain would associate with GEP overexpression.
All Author(s) ListYung MK, Lo KW, Yip CW, Chung GTY, Tong CYK, Cheung PFY, Cheung TT, Poon RTP, So S, Fan ST, Cheung ST
Journal nameBMC Cancer
Volume Number15
LanguagesEnglish-United Kingdom
KeywordsChromosome gain; Granulin-epithelin precursor; Liver cancer
Web of Science Subject CategoriesOncology

Last updated on 2021-27-11 at 00:13