An Epigenetic Regulator: Methyl-CpG-Binding Domain Protein 1 (MBD1)
Publication in refereed journal

香港中文大學研究人員

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摘要DNA methylation is an important form of epigenetic regulation in both normal development and cancer. Methyl-CpG-binding domain protein 1 (MBD1) is highly related to DNA methylation. Its MBD domain recognizes and binds to methylated CpGs. This binding allows it to trigger methylation of H3K9 and results in transcriptional repression. The CXXC3 domain of MBD1 makes it a unique member of the MBD family due to its affinity to unmethylated DNA. MBD1 acts as an epigenetic regulator via different mechanisms, such as the formation of the MCAF1/MBD1/SETDB1 complex or the MBD1-HDAC3 complex. As methylation status always changes along with carcinogenesis or neurogenesis, MBD1 with its interacting partners, including proteins and non-coding RNAs, participates in normal or pathological processes and functions in different regulatory systems. Because of the important role of MBD1 in epigenetic regulation, it is a good candidate as a therapeutic target for diseases.
著者Li L, Chen BF, Chan WY
期刊名稱International Journal of Molecular Sciences
出版年份2015
月份3
日期1
卷號16
期次3
出版社MDPI AG
頁次5125 - 5140
國際標準期刊號1661-6596
語言英式英語
Web of Science 學科類別Biochemistry & Molecular Biology; Chemistry; Chemistry, Multidisciplinary

上次更新時間 2020-21-09 於 00:57