Herb-drug interaction between an anti-HIV Chinese herbal SH formula and atazanavir in vitro and in vivo
Publication in refereed journal


引用次數
替代計量分析
.

其它資訊
摘要Ethnopharmacological relevance: With the prevalent use of highly active antiretroviral therapy (HAART) for AIDS patients since 1996, the mortality of HIV/AIDS patients has been remarkably decreased. With long-term use of HAART, drug resistance and side effects of antiretrovirals have been frequently reported, which not only reduce the efficacy, but also decreases the tolerance of patients. Traditional herbal medicine has become more popular among HIV/AIDS patients as adjuvant therapy to reduce these adverse effects of HAART. SH formula is a Chinese herbal formula consisting of five traditional Chinese herbs including Morus alba L, Glycyrrhiza glabra L, Artemisia capillaris Thumb., Astragalus membranaceus Bge., and Carthamus tinctorius L. SH formula is clinically used for HIV treatment in Thailand. However, the possible pharmacokinetic interactions between these Chinese herbs and antiretroviral drugs have not been well documented. The aim of this study was to investigate the potential herb-drug interaction between SH herbal Chinese formula and the antiretroviral drug atazanavir (ATV).
著者Cheng BH, Zhou X, Wang Y, Chan JYW, Lin HQ, Or PMY, Wan DCC, Leung PC, Fung KP, Wang YF, Lau CBS
期刊名稱Journal of Ethnopharmacology
出版年份2015
月份3
日期13
卷號162
出版社ELSEVIER IRELAND LTD
頁次369 - 376
國際標準期刊號0378-8741
語言英式英語
關鍵詞Anti-HIV; Atazanavir; CYP3A2; Herb-drug interaction; SH formula
Web of Science 學科類別Chemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy; Plant Sciences

上次更新時間 2021-20-02 於 00:05