Herb-drug interaction between an anti-HIV Chinese herbal SH formula and atazanavir in vitro and in vivo
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AbstractEthnopharmacological relevance: With the prevalent use of highly active antiretroviral therapy (HAART) for AIDS patients since 1996, the mortality of HIV/AIDS patients has been remarkably decreased. With long-term use of HAART, drug resistance and side effects of antiretrovirals have been frequently reported, which not only reduce the efficacy, but also decreases the tolerance of patients. Traditional herbal medicine has become more popular among HIV/AIDS patients as adjuvant therapy to reduce these adverse effects of HAART. SH formula is a Chinese herbal formula consisting of five traditional Chinese herbs including Morus alba L, Glycyrrhiza glabra L, Artemisia capillaris Thumb., Astragalus membranaceus Bge., and Carthamus tinctorius L. SH formula is clinically used for HIV treatment in Thailand. However, the possible pharmacokinetic interactions between these Chinese herbs and antiretroviral drugs have not been well documented. The aim of this study was to investigate the potential herb-drug interaction between SH herbal Chinese formula and the antiretroviral drug atazanavir (ATV).
All Author(s) ListCheng BH, Zhou X, Wang Y, Chan JYW, Lin HQ, Or PMY, Wan DCC, Leung PC, Fung KP, Wang YF, Lau CBS
Journal nameJournal of Ethnopharmacology
Volume Number162
Pages369 - 376
LanguagesEnglish-United Kingdom
KeywordsAnti-HIV; Atazanavir; CYP3A2; Herb-drug interaction; SH formula
Web of Science Subject CategoriesChemistry, Medicinal; Integrative & Complementary Medicine; Pharmacology & Pharmacy; Plant Sciences

Last updated on 2021-12-10 at 00:55