The Antigluconeogenic Activity of Cucurbitacins from Momordica charantia
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AbstractFive new cucurbitacins, kuguacins II-VI (1-5), along with five known analogues (6-10), were obtained from the fruit of Momordica charantia. Structures of the new compounds were elucidated as 5 beta, 19-epoxycucurbit-23-en-7-on-3 beta, 25-diol (1), 5 beta, 19-epoxycucurbit-7,23-dion-3 beta, 25-diol (2), 5 beta, 19-epoxycucurbit-6-en-19,23-dion3 beta, 25-diol (3), 5 beta, 19-epoxy-23,24,25,26,27-pentanorcucurbit-6-en-7,19-dion-3 beta, 22-diol (4), and cucurbit-5-en-7,23-dion-3 beta, 19,25-triol (5) by extensive spectroscopic and single-crystal X-ray diffraction analyses. Some cucurbitane compounds from this species were screened for their potential antidiabetic properties in terms of antigluconeogenic activity. As a result, compounds 1, 10, 11, and 12 (at 25-100 mu M) showed concentration-dependent inhibition on glucose production from liver cells. In addition, compounds 11 and 12 (at 100 mu M) showed around 20-30% inhibition on PEPCK activity.
All Author(s) ListChen JC, Lau CBS, Chan JYW, Fung KP, Leung PC, Liu JQ, Zhou L, Xie MJ, Qiu MH
Journal namePlanta Medica
Year2015
Month3
Day1
Volume Number81
Issue Number4
PublisherGeorg Thieme Verlag
Pages327 - 332
ISSN0032-0943
eISSN1439-0221
LanguagesEnglish-United Kingdom
Keywordsantigluconeogenic activity; Cucurbitaceae; cucurbitacin; kuguacins II-VI; Momordica charantia; PEPCK activity
Web of Science Subject CategoriesChemistry, Medicinal; Pharmacology & Pharmacy; Plant Sciences

Last updated on 2020-19-05 at 01:24