Inhibition of Foxp3 in cancer cells induces apoptosis of thyroid cancer cells
Publication in refereed journal


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摘要Foxp3+ regulatory T cells (Tregs) in lymphocytes facilitate the thyroid tumor growth and invasion. Very limited information is available on Foxp3 expression in thyroid cancer cells and its function is totally unknown. This study demonstrated that Foxp3 expression was increased in thyroid cancer cells. Inhibition of Foxp3 decreased cell proliferation and migration, but increased apoptosis, suggesting a positive role of Foxp3 in cancer growth. Interestingly, Foxp3 inhibition enhanced PPAR gamma expression and activity. In addition, Foxp3 inhibition downregulated NF-kappa B subunit p65 and cyclin D1 but upregulated caspase-3 levels. These molecular changes are in line with Foxp3 shRNA-mediated alteration of cell functions. Collectively, our study demonstrates that thyroid cancer cells express a high level of functional Foxp3 and that the inhibition of the Foxp3 suppresses the proliferation and migration but promotes apoptosis, suggesting that targeting Foxp3 in thyroid cancer cells may offer a novel therapeutic option for thyroid cancer. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
著者Chu R, Liu SYW, Vlantis AC, van Hasselt CA, Ng EKW, Fan MD, Ng SK, Chan ASW, Du J, Wei W, Liu XL, Liu ZM, Chen GG
期刊名稱Molecular and Cellular Endocrinology
出版年份2015
月份1
日期5
卷號399
期次C
出版社ELSEVIER IRELAND LTD
頁次228 - 234
國際標準期刊號0303-7207
語言英式英語
關鍵詞Apoptosis; Foxp3; PPAR gamma; Thyroid cancer
Web of Science 學科類別Cell Biology; Endocrinology & Metabolism

上次更新時間 2020-10-10 於 23:31