Heat Shock 70-kDa Protein 5 (Hspa5) Is Essential for Pronephros Formation by Mediating Retinoic Acid Signaling
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AbstractBackground: The function of Hspa5 in early embryonic development is not well understood. Results: Hspa5 is involved in mediating retinoic acid signaling and is required for pronephros. Conclusion: Hspa5 is essential for pronephros formation by mediating retinoic acid signaling. Significance: This is the first report on the cross-talk between physiological ER stress and transduction of retinoic acid signaling.
All Author(s) ListShi WL, Xu G, Wang CD, Sperber SM, Chen YL, Zhou Q, Deng Y, Zhao H
Journal nameJournal of Biological Chemistry
Volume Number290
Issue Number1
PublisherAmerican Society for Biochemistry and Molecular Biology
Pages577 - 589
LanguagesEnglish-United Kingdom
KeywordsDevelopment; Embryo; Endoplasmic Reticulum Stress (ER Stress); Kidney; Retinoic Acid; Xenopus
Web of Science Subject CategoriesBiochemistry & Molecular Biology

Last updated on 2020-21-09 at 00:49