Assessment of the relative performance of a confined impinging jets mixer and a multi-inlet vortex mixer for curcumin nanoparticle production
Publication in refereed journal

香港中文大學研究人員

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摘要The relative performance of two specially designed mixers for nanoparticle production, namely, two-stream confined impinging jets with dilution mixer (CIJ-D-M) and four-stream multi-inlet vortex mixer (MIVM), was evaluated using the model compound, curcumin (CUR), under defined conditions of varying mixing rate and organic solvent. In the absence of turbulent fluctuations, higher mixing rate tended to generate finer particles. Among the three water-miscible organic solvents tested, acetone afforded the smallest particle size and the narrowest particle size distribution. Both mixers were capable of reproducibly fabricating CUR nanoparticles with particle size below 100 nm and high encapsulation efficiency (>99.9%). Specifically, CIJ-D-M yielded nanoparticies with smaller size and polydispersity index while the particles obtained by the MIVM displayed better short-term stability. In addition, CIJ-D-M tended to produce a mixture of irregular nanoaggregates and primary nanoparticles while roughly spherical nanoparticles were generated with the MIVM. The observed particle size and morphological differences could be attributed to the differences in the configuration of the mixing chamber and the related mixing order. (C) 2014 Elsevier B.V. All rights reserved.
著者Chow SF, Sun CC, Chow AHL
期刊名稱European Journal of Pharmaceutics and Biopharmaceutics
出版年份2014
月份10
日期1
卷號88
期次2
出版社Elsevier
頁次462 - 471
國際標準期刊號0939-6411
電子國際標準期刊號1873-3441
語言英式英語
關鍵詞Confined impinging jets with dilution mixer; Curcumin; Diffusion; Flash nanoprecipitation; Mixing; Multi-inlet vortex mixer; Nanoparticles
Web of Science 學科類別Pharmacology & Pharmacy

上次更新時間 2020-18-09 於 01:11