Assessment of the relative performance of a confined impinging jets mixer and a multi-inlet vortex mixer for curcumin nanoparticle production
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AbstractThe relative performance of two specially designed mixers for nanoparticle production, namely, two-stream confined impinging jets with dilution mixer (CIJ-D-M) and four-stream multi-inlet vortex mixer (MIVM), was evaluated using the model compound, curcumin (CUR), under defined conditions of varying mixing rate and organic solvent. In the absence of turbulent fluctuations, higher mixing rate tended to generate finer particles. Among the three water-miscible organic solvents tested, acetone afforded the smallest particle size and the narrowest particle size distribution. Both mixers were capable of reproducibly fabricating CUR nanoparticles with particle size below 100 nm and high encapsulation efficiency (>99.9%). Specifically, CIJ-D-M yielded nanoparticies with smaller size and polydispersity index while the particles obtained by the MIVM displayed better short-term stability. In addition, CIJ-D-M tended to produce a mixture of irregular nanoaggregates and primary nanoparticles while roughly spherical nanoparticles were generated with the MIVM. The observed particle size and morphological differences could be attributed to the differences in the configuration of the mixing chamber and the related mixing order. (C) 2014 Elsevier B.V. All rights reserved.
All Author(s) ListChow SF, Sun CC, Chow AHL
Journal nameEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume Number88
Issue Number2
Pages462 - 471
LanguagesEnglish-United Kingdom
KeywordsConfined impinging jets with dilution mixer; Curcumin; Diffusion; Flash nanoprecipitation; Mixing; Multi-inlet vortex mixer; Nanoparticles
Web of Science Subject CategoriesPharmacology & Pharmacy

Last updated on 2021-12-10 at 00:53