A Novel Selenadiazole Derivative Induces Apoptosis in Human Glioma Cells by Dephosphorylation of AKT
Publication in refereed journal

香港中文大學研究人員

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摘要Selenadiazole derivatives are synthetic organoselenium compounds with improved anticancer activity and greater selectivity than inorganic selenium. In this study, 4-(benzo[c][1,2,5]selenadiazol-6-yl)-benzene-1,2-diamine (BSBD) was shown to induce time- and dose-dependent apoptosis in SWO-38 human glioma cells by accumulation of a sub-G1 cell population, DNA fragmentation, nuclear condensation, caspase activation and poly(ADP-ribose) polymerase (PARP) cleavage. Further mechanistic investigation showed that BSBD treatment induced dephosphorylation of AKT and DNA damage-mediated activation of p53, leading to extensive apoptosis through the mitochondrial pathway. Our findings suggest that BSBD represents a potential human glioma therapeutic.
著者Zhang YK, Zheng SY, Ngai SM, Zheng WJ, Li JY, Chen TF, Zhong XY
期刊名稱Chemical and Pharmaceutical Bulletin
出版年份2014
月份10
日期1
卷號62
期次10
出版社PHARMACEUTICAL SOC JAPAN
頁次994 - 999
國際標準期刊號0009-2363
語言英式英語
關鍵詞apoptosis; glioma; organoselenium compound; selenium; signal transduction
Web of Science 學科類別Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy

上次更新時間 2020-22-10 於 00:07