A Novel Selenadiazole Derivative Induces Apoptosis in Human Glioma Cells by Dephosphorylation of AKT
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AbstractSelenadiazole derivatives are synthetic organoselenium compounds with improved anticancer activity and greater selectivity than inorganic selenium. In this study, 4-(benzo[c][1,2,5]selenadiazol-6-yl)-benzene-1,2-diamine (BSBD) was shown to induce time- and dose-dependent apoptosis in SWO-38 human glioma cells by accumulation of a sub-G1 cell population, DNA fragmentation, nuclear condensation, caspase activation and poly(ADP-ribose) polymerase (PARP) cleavage. Further mechanistic investigation showed that BSBD treatment induced dephosphorylation of AKT and DNA damage-mediated activation of p53, leading to extensive apoptosis through the mitochondrial pathway. Our findings suggest that BSBD represents a potential human glioma therapeutic.
All Author(s) ListZhang YK, Zheng SY, Ngai SM, Zheng WJ, Li JY, Chen TF, Zhong XY
Journal nameChemical and Pharmaceutical Bulletin
Volume Number62
Issue Number10
Pages994 - 999
LanguagesEnglish-United Kingdom
Keywordsapoptosis; glioma; organoselenium compound; selenium; signal transduction
Web of Science Subject CategoriesChemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy

Last updated on 2020-21-09 at 00:44