A Novel Selenadiazole Derivative Induces Apoptosis in Human Glioma Cells by Dephosphorylation of AKT
Publication in refereed journal


Times Cited
Web of Science7WOS source URL (as at 20/09/2020) Click here for the latest count
Altmetrics Information
.

Other information
AbstractSelenadiazole derivatives are synthetic organoselenium compounds with improved anticancer activity and greater selectivity than inorganic selenium. In this study, 4-(benzo[c][1,2,5]selenadiazol-6-yl)-benzene-1,2-diamine (BSBD) was shown to induce time- and dose-dependent apoptosis in SWO-38 human glioma cells by accumulation of a sub-G1 cell population, DNA fragmentation, nuclear condensation, caspase activation and poly(ADP-ribose) polymerase (PARP) cleavage. Further mechanistic investigation showed that BSBD treatment induced dephosphorylation of AKT and DNA damage-mediated activation of p53, leading to extensive apoptosis through the mitochondrial pathway. Our findings suggest that BSBD represents a potential human glioma therapeutic.
All Author(s) ListZhang YK, Zheng SY, Ngai SM, Zheng WJ, Li JY, Chen TF, Zhong XY
Journal nameChemical and Pharmaceutical Bulletin
Year2014
Month10
Day1
Volume Number62
Issue Number10
PublisherPHARMACEUTICAL SOC JAPAN
Pages994 - 999
ISSN0009-2363
LanguagesEnglish-United Kingdom
Keywordsapoptosis; glioma; organoselenium compound; selenium; signal transduction
Web of Science Subject CategoriesChemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology & Pharmacy

Last updated on 2020-21-09 at 00:44