Accuracy and Uncertainty of Asymmetric Magnetization Transfer Ratio Quantification for Amide Proton Transfer (APT) Imaging at 3T: A Monte Carlo Study
Refereed conference paper presented and published in conference proceedings

香港中文大學研究人員

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摘要Amide proton transfer (APT) imaging offers a novel and powerful MRI contrast mechanism for quantitative molecular imaging based on the principle of chemical exchange saturation transfer (CEST). Asymmetric magnetization transfer ratio (MTRasym) quantification is crucial for Z-spectrum analysis of APT imaging, but is still challenging, particularly at clinical field strength. This paper studies the accuracy and uncertainty in the quantification of MTRasym for APT imaging at 3T, by using high-order polynomial fitting of Z-spectrum through Monte Carlo simulation. Results show that polynomial fitting is a biased estimator that consistently underestimates MTRasym. For a fixed polynomial order, the accuracy of MTRasym is almost constant with regard to signal-to-noise ratio (SNR) while the uncertainty decreases exponentially with SNR. The higher order polynomial fitting increases both the accuracy and the uncertainty of MTRasym. For different APT signal intensity levels, the relative accuracy and the absolute uncertainty keep constant for a fixed polynomial order. These results indicate the limitations and pitfalls of polynomial fitting for MTRasym quantification so better quantification technique for MTRasym estimation is warranted.
著者Yuan J, Zhang QW, Wang YX, Wei J, Zhou JY
會議名稱35th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC)
會議開始日03.07.2013
會議完結日07.07.2013
會議地點Osaka
會議國家/地區日本
期刊名稱Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
詳細描述organized by IEEE, EMB, JSMBE,
出版年份2013
月份1
日期1
出版社IEEE
頁次5139 - 5142
電子國際標準書號978-1-4577-0216-7
國際標準期刊號1557-170X
語言英式英語
Web of Science 學科類別Engineering; Engineering, Biomedical; Engineering, Electrical & Electronic

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