Cramer-Rao Bound for Intravoxel Incoherent Motion Diffusion Weighted Imaging Fitting
Refereed conference paper presented and published in conference proceedings

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AbstractThe precision of parameter estimation for Intravoxel Incoherent Motion Diffusion Weighted Imaging (IVIM-DWI) was investigated by examining their Cramer-Rao bounds (CRBs) under the presence of Rician noise. Monte Carlo (MC) simulation was also conducted to validate the CRB results. The estimation uncertainties of true diffusion coefficient (D) and perfusion fraction (f(0)) could reach 3.89% and 11.65% respectively with typical parameter values at a moderate signal-to-noise ratio (SNR) of 40. However, to estimate pseudo diffusion coefficient (D*) within 10% uncertainty requires SNR>122. The results also showed that the estimation precision of each parameter is not only dependent on SNR but also their true values, while this mutual dependency is complicated. Under some particular cases, estimation uncertainty for certain parameters might be smaller than 5% at a moderate SNR of 40. However, the simultaneous precise estimation for all three parameters is theoretically difficult and highly SNR demanding.
All Author(s) ListZhang QW, Wang YX, Ma HT, Yuan J
Name of Conference35th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC)
Start Date of Conference03/07/2013
End Date of Conference07/07/2013
Place of ConferenceOsaka
Country/Region of ConferenceJapan
Journal nameConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Detailed descriptionorganized by IEEE, EMB, JSMBE,
Pages511 - 514
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesEngineering; Engineering, Biomedical; Engineering, Electrical & Electronic

Last updated on 2021-11-04 at 00:00