miR-31 is consistently inactivated in EBV-associated nasopharyngeal carcinoma and contributes to its tumorigenesis
Publication in refereed journal


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摘要Background: As a distinctive type of head and neck cancers, nasopharyngeal carcinoma (NPC) is genesis from the clonal Epstein-Barr virus (EBV)-infected nasopharyngeal epithelial cells accumulated with multiple genetic lesions. Among the recurrent genetic alterations defined, loss of 9p21.3 is the most frequent early event in the tumorigenesis of EBV-associated NPC. In addition to the reported CDKN2A/p16, herein, we elucidated the role of a miRNA, miR-31 within this 9p21.3 region as NPC-associated tumor suppressor.
著者Cheung CCM, Chung GTY, Lun SWM, To KF, Choy KW, Lau KM, Siu SPK, Guan XY, Ngan RKC, Yip TTC, Busson P, Tsao SW, Lo KW
期刊名稱Molecular Cancer
詳細描述doi: 10.1186/1476-4598-13-184.
出版年份2014
月份8
日期7
卷號13
出版社BIOMED CENTRAL LTD
國際標準期刊號1476-4598
語言英式英語
關鍵詞FIH1; MCM2; MicroRNA; miR-31; Nasopharyngeal carcinoma
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Oncology; ONCOLOGY

上次更新時間 2020-27-10 於 01:18