miR-31 is consistently inactivated in EBV-associated nasopharyngeal carcinoma and contributes to its tumorigenesis
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AbstractBackground: As a distinctive type of head and neck cancers, nasopharyngeal carcinoma (NPC) is genesis from the clonal Epstein-Barr virus (EBV)-infected nasopharyngeal epithelial cells accumulated with multiple genetic lesions. Among the recurrent genetic alterations defined, loss of 9p21.3 is the most frequent early event in the tumorigenesis of EBV-associated NPC. In addition to the reported CDKN2A/p16, herein, we elucidated the role of a miRNA, miR-31 within this 9p21.3 region as NPC-associated tumor suppressor.
All Author(s) ListCheung CCM, Chung GTY, Lun SWM, To KF, Choy KW, Lau KM, Siu SPK, Guan XY, Ngan RKC, Yip TTC, Busson P, Tsao SW, Lo KW
Journal nameMolecular Cancer
Detailed descriptiondoi: 10.1186/1476-4598-13-184.
Volume Number13
LanguagesEnglish-United Kingdom
KeywordsFIH1; MCM2; MicroRNA; miR-31; Nasopharyngeal carcinoma
Web of Science Subject CategoriesBiochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY; Oncology; ONCOLOGY

Last updated on 2020-17-09 at 02:04