Sclerostin Monoclonal Antibody Enhanced Bone Fracture Healing in an Open Osteotomy Model in Rats
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AbstractSclerostin is a negative regulator of bone formation. Sclerostin monoclonal antibody (Scl-Ab) treatment promoted bone healing in various animal models. To further evaluate the healing efficiency of Scl-Ab in osteotomy healing, we investigated the time course effects of systemic administration of Scl-Ab on fracture repair in rat femoral osteotomy model. A total of 120 six-month-old male SD rats were subjected to transverse osteotomy at the right femur mid-shaft. Rats were treated with vehicle or Scl-Ab treatment for 3, 6, or 9 weeks. Fracture healing was evaluated by radiography, micro-CT, micro-CT based angiography, 4-point bending mechanical test and histological assessment. Scl-Ab treatment resulted in significantly higher total mineralized callus volume fraction, BMD and enhanced neovascularization. Histologically, Scl-Ab treatment resulted in a significant reduction in fracture callus cartilage at week 6 and increase in bone volume at week 9, associated with a greater proportion of newly formed bone area at week 6 and 9 by fluorescence microscopy. Mechanical testing showed significantly higher ultimate load in Scl-Ab treatment group at week 6 and 9. This study has demonstrated that Scl-Ab treatment enhanced bone healing in a rat femoral osteotomy model, as reflected in increased bone formation, bone mass and bone strength. (C) 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
All Author(s) ListSuen PK, He YX, Chow DHK, Huang L, Li CY, Ke HZ, Ominsky MS, Qin L
Journal nameJournal of Orthopaedic Research
Volume Number32
Issue Number8
PublisherWiley: 12 months
Pages997 - 1005
LanguagesEnglish-United Kingdom
Keywordsfracture healing; osteotomy; sclerostin; sclerostin monoclonal antibody
Web of Science Subject CategoriesOrthopedics; ORTHOPEDICS

Last updated on 2021-14-01 at 23:42