In Vivo Chemoembolization and Magnetic Resonance Imaging of Liver Tumors by Using Iron Oxide Nanoshell/Doxorubicin/Poly(vinyl alcohol) Hybrid Composites
Publication in refereed journal


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摘要A hybrid composite made up of superparamagnetic iron oxide nanoshells encapsulating the anticancer drug doxorubicin and bound together by poly(vinyl alcohol) was developed. Transcatheter arterial delivery in an invivo liver tumor model led to embolization of the liver tumor blood vessels. Embolization was followed by disassembly of the composite. The nanoshells were then able to pass through the leaky tumor vasculature into the tumor tissue, thereby leading to slow and sustained release of the drug. As well as being relatively noncytotoxic, the composite was responsive to magnetic resonance imaging, thus making it a potentially useful theranostic agent.
著者Wang YXJ, Zhu XM, Liang Q, Cheng CHK, Wang W, Leung KCF
期刊名稱Angewandte Chemie International Edition
詳細描述To ORKTS: doi: 10.1002/anie.201402144
出版年份2014
月份5
日期5
卷號53
期次19
出版社Wiley: 12 months
頁次4812 - 4815
國際標準期刊號1433-7851
電子國際標準期刊號1521-3773
語言英式英語
關鍵詞antitumor agents; chemoembolization; drug delivery; iron oxide; liver cancer
Web of Science 學科類別Chemistry; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY

上次更新時間 2021-23-02 於 00:16