In Vivo Chemoembolization and Magnetic Resonance Imaging of Liver Tumors by Using Iron Oxide Nanoshell/Doxorubicin/Poly(vinyl alcohol) Hybrid Composites
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AbstractA hybrid composite made up of superparamagnetic iron oxide nanoshells encapsulating the anticancer drug doxorubicin and bound together by poly(vinyl alcohol) was developed. Transcatheter arterial delivery in an invivo liver tumor model led to embolization of the liver tumor blood vessels. Embolization was followed by disassembly of the composite. The nanoshells were then able to pass through the leaky tumor vasculature into the tumor tissue, thereby leading to slow and sustained release of the drug. As well as being relatively noncytotoxic, the composite was responsive to magnetic resonance imaging, thus making it a potentially useful theranostic agent.
All Author(s) ListWang YXJ, Zhu XM, Liang Q, Cheng CHK, Wang W, Leung KCF
Journal nameAngewandte Chemie International Edition
Detailed descriptionTo ORKTS: doi: 10.1002/anie.201402144
Year2014
Month5
Day5
Volume Number53
Issue Number19
PublisherWiley: 12 months
Pages4812 - 4815
ISSN1433-7851
eISSN1521-3773
LanguagesEnglish-United Kingdom
Keywordsantitumor agents; chemoembolization; drug delivery; iron oxide; liver cancer
Web of Science Subject CategoriesChemistry; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY

Last updated on 2021-22-01 at 00:29