Delivery of Poorly Soluble Compounds by Amorphous Solid Dispersions
Publication in refereed journal


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摘要Solid state manipulation by amorphous solid dispersion has been the subject of intensive research for decades due to their excellent potential for dissolution and bioavailability enhancement. The present review aims to highlight the latest advancement in this area, with focus on the fundamentals, characterization, formulation development and manufacturing of amorphous solid dispersions as well as the new generation amorphization technologies. Additionally, specific applications of amorphous solid dispersion in the formulation of herbal drugs or bioactive natural products are reviewed to reflect the growing interest in this relatively neglected area.
著者Lee TWY, Boersen NA, Hui HW, Chow SF, Wan KY, Chow AHL
期刊名稱Current Pharmaceutical Design
出版年份2014
月份1
日期1
卷號20
期次3
出版社Bentham Science Publishers
頁次303 - 324
國際標準期刊號1381-6128
電子國際標準期刊號1873-4286
語言英式英語
關鍵詞amorphization technologies; Amorphous solid dispersion; glass transition; molecular mobility; physical stability; polymer carrier
Web of Science 學科類別Pharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

上次更新時間 2020-26-09 於 23:14