Delivery of Poorly Soluble Compounds by Amorphous Solid Dispersions
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AbstractSolid state manipulation by amorphous solid dispersion has been the subject of intensive research for decades due to their excellent potential for dissolution and bioavailability enhancement. The present review aims to highlight the latest advancement in this area, with focus on the fundamentals, characterization, formulation development and manufacturing of amorphous solid dispersions as well as the new generation amorphization technologies. Additionally, specific applications of amorphous solid dispersion in the formulation of herbal drugs or bioactive natural products are reviewed to reflect the growing interest in this relatively neglected area.
All Author(s) ListLee TWY, Boersen NA, Hui HW, Chow SF, Wan KY, Chow AHL
Journal nameCurrent Pharmaceutical Design
Year2014
Month1
Day1
Volume Number20
Issue Number3
PublisherBentham Science Publishers
Pages303 - 324
ISSN1381-6128
eISSN1873-4286
LanguagesEnglish-United Kingdom
Keywordsamorphization technologies; Amorphous solid dispersion; glass transition; molecular mobility; physical stability; polymer carrier
Web of Science Subject CategoriesPharmacology & Pharmacy; PHARMACOLOGY & PHARMACY

Last updated on 2020-17-10 at 00:00