Emerging Roles of Small Epstein-Barr Virus Derived Non-Coding RNAs in Epithelial Malignancy
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AbstractLatent Epstein-Barr virus (EBV) infection is an etiological factor in the progression of several human epithelial malignancies such as nasopharyngeal carcinoma (NPC) and a subset of gastric carcinoma. Reports have shown that EBV produces several viral oncoproteins, yet their pathological roles in carcinogenesis are not fully elucidated. Studies on the recently discovered of EBV-encoded microRNAs (ebv-miRNAs) showed that these small molecules function as post-transcriptional gene regulators and may play a role in the carcinogenesis process. In NPC and EBV positive gastric carcinoma (EBVaGC), 22 viral miRNAs which are located in the long alternative splicing EBV transcripts, named BamH1 A rightward transcripts (BARTs), are abundantly expressed. The importance of several miR-BARTs in carcinogenesis has recently been demonstrated. These novel findings enhance our understanding of the oncogenic properties of EBV and may lead to a more effective design of therapeutic regimens to combat EBV-associated malignancies. This article will review the pathological roles of miR-BARTs in modulating the expression of cancer-related genes in both host and viral genomes. The expression of other small non-coding RNAs in NPC and the expression pattern of miR-BARTs in rare EBV-associated epithelial cancers will also be discussed.
All Author(s) ListLung RWM, Tong JHM, To KF
Journal nameInternational Journal of Molecular Sciences
Year2013
Month9
Day1
Volume Number14
Issue Number9
PublisherMDPI AG
Pages17378 - 17409
ISSN1661-6596
LanguagesEnglish-United Kingdom
KeywordsBART; EBV-associated gastric carcinoma (EBVaGC); Epstein-Barr virus (EBV); lymphoepithelioma-like carcinoma (LELC) of the lung; lymphoepithelioma-like cholangiocarcinoma; miRNAs; nasopharyngeal carcinoma (NPC); v-snoRNA1
Web of Science Subject CategoriesBiochemistry & Molecular Biology; Chemistry; Chemistry, Multidisciplinary; CHEMISTRY, MULTIDISCIPLINARY

Last updated on 2020-30-09 at 00:02