Expression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in breast cancers
Publication in refereed journal

香港中文大學研究人員

引用次數
替代計量分析
.

其它資訊
摘要Carcino-embryonic antigen-related cell adhesion molecule 6 (CEACAM6), one of the members of human carcino-embryonic antigens, is a multifunctional regulatory protein involved in various cellular processes in cancers. Its role in malignant transformation and the clinical significance has been extensively studied in colonic and pancreatic cancers. However, relatively few studies have been done on breast cancers. In the current study, CEACAM6 expression in two independent cohorts of invasive breast cancers were evaluated immunohistochemically and correlated with clinico-pathological features, biomarker profiles and patient survival. In the primary cohort, CEACAM6 expression was detected in 37.1 % (312/840) of primary invasive cancers. It was positively correlated with HER2 (p < 0.001). Concordantly, HER2-OE subtype showed the highest CEACAM6 expression (62.7 %) among all molecular subtypes; whereas, other subtypes also showed substantial CEACAM6 expression (21.8-37.5 %). Interestingly, a significantly worse overall survival was found in high pN stage HER2 positive cancers with CEACAM6 positivity (log-rank = 4.452, p = 0.035) and this could be validated in an independent cohort. Additionally, HER2 signaling was found to induce SMAD3 phosphorylation and CEACAM6 expression in a cell line model. Likewise, in the primary tumors, a positive association was found between HER2 and SMAD3 phosphorylation in CEACAM6 positive cancers (p = 0.012). Overall, CEACAM6 was widely expressed in different molecular subtypes, but highest and significantly in HER2-OE breast cancer. Within this group, CEACAM6 was associated with adverse high nodal stage patient outcome. Given the wide expression of CEACAM6 in all breast cancers, its roles as prognostic marker and therapeutic target warrant further evaluation.
著者Tsang JYS, Kwok YK, Chan KW, Ni YB, Chow WNV, Lau KF, Shao MM, Chan SK, Tan PH, Tse GM
期刊名稱Breast Cancer Research and Treatment
出版年份2013
月份11
日期1
卷號142
期次2
出版社Springer Verlag (Germany)
頁次311 - 322
國際標準期刊號0167-6806
電子國際標準期刊號1573-7217
語言英式英語
關鍵詞Breast cancer; CEACAM6; HER2; Immunohistochemistry; Nodal stages
Web of Science 學科類別Oncology; ONCOLOGY

上次更新時間 2021-26-01 於 00:37