Thrombopoietin improved ventricular function and regulated remodeling genes in a rat model of myocardial infarction
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AbstractBackground: Thrombopoietin (TPO) protects against heart damages by doxorubicin-induced cardiomyopathy in animal models. We aimed to investigate the therapeutic efficacy of TPO for treatment of myocardial infarction (MI) in a rat model and explored the mechanisms in terms of the genome-wide transcriptional profile, TPO downstream protein signals, and bone marrow endothelial progenitor cells (EPCs).
All Author(s) ListChan KYY, Zhou LG, Xiang P, Li KR, Ng PC, Wang CC, Li M, Pong NH, Tu L, Deng HY, Kong CKL, Sung RYT
Journal nameInternational Journal of Cardiology
Detailed description167:2546-54
Volume Number167
Issue Number6
Pages2546 - 2554
LanguagesEnglish-United Kingdom
KeywordsCardiac remodeling; Endothelial progenitor cells; Microarray profiling; Myocardial infarction; Thrombopoietin
Web of Science Subject CategoriesCardiac & Cardiovascular Systems; CARDIAC & CARDIOVASCULAR SYSTEMS; Cardiovascular System & Cardiology

Last updated on 2020-27-10 at 00:46