Studies on Anticancer Activities of Lactoferrin and Lactoferricin
Publication in refereed journal


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摘要This review mainly summarizes results of recent studies on the anticancer activity of the multifunctional protein lactoferrin (Lf) and its derived peptide lactoferricin (Lfcin). The basic information on Lf and Lfcin, such as their sources, structures, and biological properties which favor their antitumor activity is introduced. The major anticancer mechanisms of Lf and Lfcin including cell cycle arrest, apoptosis, anti-angiogenesis, antimetastasis, immune modulation and necrosis are discussed. Other information from in vivo studies employing a mouse model is also provided. In addition, the roles of talatoferrin and delta lactoferrin, as well as improvement in drug delivery will be covered.
著者Yin CM, Wong JH, Xia J, Ng TB
期刊名稱Current Protein and Peptide Science
詳細描述To ORKTS: doi:10.2174/13892037113149990066.
Updated this record and deleted duplicated record (P137384) on 24-Feb-2015.
出版年份2013
月份9
日期1
卷號14
期次6
出版社Bentham Science Publishers
頁次492 - 503
國際標準期刊號1389-2037
電子國際標準期刊號1875-5550
語言英式英語
關鍵詞Application; cancer; delta lactoferrin; drug delivery; lactoferricin; lactoferrin; mechanism; talactoferrin
Web of Science 學科類別Biochemistry & Molecular Biology; BIOCHEMISTRY & MOLECULAR BIOLOGY

上次更新時間 2020-27-10 於 00:45